The Nationwide Cancer Genome Screening Projects For Gastrointestinal Cancer In Japan (Scrum-Japan Gi-Screen): Efficient Identification Of Actionable Cancer Genome Alterations In Advanced Colorectal And Non-Colorectal Gastrointestinal Cancer (Gi Screen 2013-01-Crc And 2015-01-Non Crc).

TPS4134 Background: Several cancer genome alterations have been identified as important targets for treatment. Example of possible candidates in gastrointestinal (GI) cancer include BRAF mutations in colorectal cancer (CRC) or MET amplification in gastric cancer, for which corresponding targeting agents showed attractive activity in early phase clinical trials. Efficient screening systems for these relatively minor cancer genome alterations are necessary for the successful development of targeted therapies. We initiated a nationwide screening project in Japan (GI-SCREEN) in February 2014 to detect rare mutations from CRC (GI-SCREEN 2013-01-CRC). The patient’s population will be expanded to non-CRC GI cancer (SCRUM-Japan GI-SCREEN 2015-01-Non CRC). The objective of these consecutive projects is to evaluate the frequency of oncogenic genome alterations in advanced GI cancers and to facilitate the enrollment of patients in IND registration trials for targeted therapies as well as optimal individualized treat...