Asco 2014: High Prevalence Of Flt-3 Itd Mutations In Patients (Pts) With Aml Who Present With Cns Relapse.

7074 Background: Despite CR rates of 70% with modern chemotherapeutic regimens, most pts with AML relapse. CNS relapses have become uncommon with the use of high-dose cytarabine based regimens. The features associated with a higher risk of CNS relapse are not defined. Methods: We analyzed adults who presented with AML and CNS relapses from 2000 until 2014. CNS leukemia was diagnosed by the presence of blasts in a cytocentrifuge preparation of CSF. Pts with blasts in the CSF together with high numbers of red blood cells (u003e 5) were not considered to have CNS disease if the blasts were high in the PB. Results: Of the 1312 pts with AML treated at our institution, 71 (5%) had CNS disease. Median age was 57 years. CNS involvement was detected after a median of 8 months from the initial diagnosis. 4 pts (6%) had isolated CNS relapse that was followed by systemic relapse after a median of 2 weeks. CNS involvement was detected in the setting of refractory AML in 31 pts (44%). 64 pts (90%) received previous high-do...