Effect Of 12-Week Home-Based Exercise Program On Fasting Insulin In Stage Ii-Iii Colorectal Cancer Survivors: A Randomized Controlled Trial.

3588 Background: High insulin levels may be associated with an increased risk of colorectal cancer (CRC) development and recurrence. However, the effect of exercise on fasting insulin level in colorectal cancer survivors has not been fully studied. We conducted a randomized control trial to determine the effect of a 12-week home based exercise program on fasting insulin, body composition, and fitness in stage II-III CRC survivors. Methods: 123 stage II-III CRC survivors between 4 and 102 weeks after standard cancer therapy (surgery, chemotherapy, and/or radiation therapy) were randomly assigned to either the 12-week home-based exercise (n=62) or usual care (n=61) group. The goal of the home-based exercise was to increase the level of physical activity of the participants to 18-27 MET hours per week. The primary outcome measurement was fasting insulin and secondary outcome measurements were body composition and fitness level. Results: A total of 99 (80.5%) participants completed the trial. After 12 week of...