Comprehensive Genomic Profiling (Cgp) Of Cervical Squamous Cell Carcinoma (Cscc) To Identifiy Targeted Therapy Options.

5602 Background: High risk HPV initiates neoplasia in cSCC and progression requires additional genomic alterations (GA). Treatment of localized cSCC is effective but the response to systemic therapy for metastatic disease is inadequate. CGP of 99 advanced stage cSCC was undertaken to identify GA associated with targeted therapeutic options relevant to the systemic treatment of cSCC. Methods: DNA was extracted from 99 FFPE cSCC clinical specimens. Hybridization captured libraries of 236 (FoundationOne, n = 66) or 305 (FoundationOne, n = 33) genes, plus select introns frequently rearranged in cancer were sequenced to high ( u003e 450x), uniform coverage. HPV16 and HPV 18 viral sequences were detected, but other hrHPVs were not assayed. All classes of genomic alterations (base subs, small in/dels, rearrangements, and copy number alterations) were evaluated and reported. CRGA were defined as GA associated with on-label targeted therapies and targeted therapies in mechanism-driven clinical trials. Results: 99 samp...