Adherence To Regorafenib Therapy In Patients With Metastatic Colorectal Cancerpreviously Treated Metastatic Colorectal Cancer: Sti Observational Multicenter Study.

e17529 Background: Oral agents for anticancer therapy provide an attractive approach for patient acceptance and use of oral treatments is increasing. Adherence can be defined as the extent to which a patient’s behavior coincides with medical advice. Patient Adherence is critical in evaluating the effectiveness of an oral therapy. We sought to measure acceptance and adherence among patients with metastatic colorectal cancer previously treated with chemotherapy and other target therapy agents. Methods: Overall 64 patients with histologically proven metastatic colorectal cancer treated with oral regorafenib 160 mg once dailywere enrolled. The level of acceptance was evaluated using a questionnaire with ten questions administered every 2 months thereafter during the treatment. Patients scored each item on a 5-point ordinal scale range ranging from 0 to 4 during the previous 7 days. The adherence to the treatment was measured using the patient-completed medication diaries, the physician interview and pill coun...