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Mechanism Research of Reversal in Multidrug Resistance by Magnetic Nanoparticle Fe3O4 Syndesis with 5-Bromotetrandrine and Daunomycin

Bao-An Chen,Wei-wei Wu,Jian Cheng,Feng Gao,Wen-lin Xu,Hui-lin Shen,Jia-hua Ding,Chong Gao,Yun-Yu Sun,Jun Wang,Gang Zhao,Huihui Song,Wen Bao,Xin-chen Sun,Hong-yan Cheng,Yu-xia Deng,Guo-hong Li,Li-jie Liu,Wen-ji Chen,Jue-qiong Wang

Blood（2008）

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Abstract
Objective To evaluate the MDR reversal activity of magnetic nanoparticle Fe3O4 (Nano-Fe3O4) and 5-bromotetrandrine (BrTet) on multidrug resistance cell line K562/A02 solitarily or symphysially, and to investigate the reversal mechanism of this coopration.
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