Phyto-Estrogenic Effects Of Marantodes Pumilum (Blume) Kuntze Syn. Labisia Pumila (Blume) Fern.-Vill. For The Prevention And Treatment Of Post-Menopausal Diseases

Labisia pumila (Blume) Fern.-Vill. known as Kacip Fatimah, is a herbal medicine that has been widely used for women's health. The extensive use of this plant has led to many speculations and studies on its phytochemical identification, biological and toxicological activities. Phytoestrogen is one of many phytochemical properties found in the herbal extract and has beneficial effects for post-menopausal diseases. This systematic review highlights the phytoestogenic properties of Labisia pumila for the prevention and/or treatment of post-menopausal diseases. A comprehensive search was conducted in Scopus, EBSCO host and Ovid Medline for related studies published between the years 1946 to August 2016. The main inclusion criteria were research articles published in English, and studies had to report the phytoestrogenic effects of Labisia pumila in the prevention and treatment of post-menopausal diseases. The literature search identified 142 potentially relevant articles, whereby 12 met the inclusion criteria. Eleven animal studies and one human study were included in this review. All of the studies reported positive effects of Labisia pumila on post-menopausal diseases due to estrogenic deficient state. This systematic review focused on the potential of Labisia pumila being used for treatment or prevention of diseases in the post-menopausal state.