Copper-Free Double Silylation of 1,2-Dibromobenzenes Using a Mg/LiCl/DMI System
SYNTHESIS-STUTTGART(2017)
Abstract
The reaction of 1,2-dibromobenzenes with chlorotrimethylsilane efficiently proceeded in the presence of Mg and LiCl in DMI under mild conditions, giving 1,2-bis(trimethylsilyl) benzenes in good to high yields. The reaction of 1,2-dibromobenzenes with chlorodimethylsilane under the same conditions afforded the corresponding 1,2-bis(dimethylsilyl)benzenes in high yields. Functional group transformations of 1,2bis(trimethylsilyl)benzene were conducted to demonstrate the synthetic utility.
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Key words
copper-free reaction,double silylation,1,2-bis(trimethylsilyl)benzenes,mild conditions,1,2-dibromobenzenes,Mg/LiCl/DMI system
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