A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines

SYNTHESIS-STUTTGART(2017)

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摘要
A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50-90% yield.
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关键词
copper,2-halobenzimidamides,sodium azide,catalysis,4-aminoquinazolines
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