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In vitro modulatory effects of functionalized pyrimidines and piperidine derivatives on Aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) activities

Muhammad Yar,Lubna Shahzadi,Ariba Farooq,Saima Jalil Imran,José P. Cerón-Carrasco,Helena den-Haan,Sanjay Kumar,Jorge Peña-García,Horacio Pérez-Sánchez,Aneta Grycova,Zdenek Dvorak,Radim Vrzal

Bioorganic Chemistry（2017）

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Abstract
•Molecules that can activate/deactivate certain receptors are of great medical interest.•Selected pyrimidine/piperidine derivatives were synthesized.•The in vitro evidences demonstrate these compounds might be used as the modulators of AhR and GR activities.
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Key words
Antagonists,Piperidines,Pyrimidines,Aryl hydrocarbon receptor,Glucocorticoid receptor,Biotransformation,Immunological response
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