Evaluation of the new siemens ADVIA centaur testosterone II assay

Aim: Serum testosterone is commonly analysed using immunoassays in clinical laboratories. Some immunoassays lack specificity at lower concentrations and are imprecise. Liquid chromatography tandem mass spectrometry (LCMSMS) is considered the reference method for measuring testosterone. The new Siemens ADVIA Centaur testosterone II (TSTII) assay is reported to have improved assay performance. We evaluated the TSTII assay in comparison with LCMSMS (Shimadzu LC–AB SCIEX Triple Quad 5500) and current Centaur (TSTO).