The phagosome: Meeting point of the Myddosome, NLRs, and degraded Borrelia burgdorferi

Our results show that the phagosome is a crucial cellular location not only for degradation of the spirochete, but where components of the Myddosome and inflammasome are recruited. Our findings are in line with recent studies showing that cytosolic receptors can localize to endosomal membranes, and can potentially have an alternate role in regulating an adequate functionality of the phagosome. Our study evidences the complexity of phagosomal signaling in which MyD88 plays a critical role not only in the generation of inflammatory but inducing regulatory signals in murine macrophages upon Bb infection.