TB-IRIS: Proteomic analysis of in vitro PBMC responses to Mycobacterium tuberculosis and response modulation by dexamethasone

Liam Bell,Janique M. Peyper,Shaun Garnett,Rabecca Tadokera,Robert Wilkinson,Graeme Meintjes,Jonathan M. Blackburn

Experimental and Molecular Pathology（2017）

引用 4|浏览11

暂无评分

摘要

Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) occurs in 8–54% of South African patients undergoing treatment for tuberculosis/human immunodeficiency virus co-infection. Improved TB-IRIS molecular pathogenesis understanding would enhance risk stratification, diagnosis, prognostication, and treatment. We assessed how TB-IRIS status and dexamethasone influence leukocyte proteomic responses to Mycobacterium tuberculosis (Mtb).

查看译文

关键词

Tuberculosis-HIV co-infection,Anti-retroviral therapy,Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome,Human peripheral blood mononuclear cells,Proteomics,Mass spectrometry

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要