SURG-05. NATIONAL TRENDS FOR REOPERATION IN PATIENTS WITH GLIOBLASTOMA MULTIFORME

Despite multimodal therapies extending patient survival, Glioblastoma multiforme (GBM) recurrence is all but a certainty. To date, there have only been a few single-center studies looking at reoperations. Our study aimed to assess GBM reoperation trends nationally, with emphasis on outcomes. The linked Surveillance, Epidemiology, and End Results (SEER) – Medicare database was searched to identify patients 66 years and older with GBM from 1997-2010. The primary outcome was survival after diagnosis. Kaplan-Meier curves and multivariate analysis with the proportional hazard ratios were used. A total of 3,784 patients with recurrent GBM were identified. At the time of initial diagnosis, 341 patients (9%) underwent a biopsy as the first surgery, and 3,443 patients (91%) received a gross total resection. Reoperation - whether after an initial biopsy or resection - increased survival in patients, with a median survival of 5 months in the group that did not receive reoperation vs. 11 months in the group that did (p