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Iodine-Mediated One-Pot Synthesis of 2-(Piperazin-1-yl)pyrazine Derivatives from N-Alkyl Piperazines

Ruihuan Liu,Yikun Wang,Yanmei Weng,Caiping Yao,Yan Zhang,Gangzhi Zhu,Xiaoai He,Kangping Xu,Guishan Tan

Synlett（2017）

Cited 5|Views10
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Abstract
Abstract An iodine-mediated one-pot reaction of N-alkyl piperazines is described for the first time. This transformation provides a straightforward and facile pathway to the synthesis of 2-(piperazin-1-yl)pyrazine derivatives with the corresponding N-alkyl piperazines as single material. Based on a series of control experiments, a plausible reaction mechanism has been proposed.
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Key words
iodine,sodium acetate,one-pot reaction,2-(piperazin-1-yl)pyrazine,N-alkyl piperazine
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