Development of Cathepsin B Positive Modulators to Treat Multi-Proteinopathic Dementias: Exploiting the Lysosomal Avenue of Protein Clearance to Promote Synaptic Recovery

Morgan C. Pait,Lyndsie Elliott, Sarah Hafner-Ruiz,Cary Mundell, Walter Patterson,Heather Romine,Uzoma S. Ikonne,Ben A. Bahr

FASEB JOURNAL（2016）

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摘要

Alzheimer’s disease (AD) is characterized by pathological assembly states of Aβ42, tau aggregates, and other age-related protein accumulations. Inefficient clearance contributes to AD, thus our dru...

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promote synaptic recovery,lysosomal,multi-proteinopathic clearance

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