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Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells

Liuhong Li,Qiuyun Tu,Xiao-Hua Deng,Jian Xia,De-Ren Hou,Ke Guo,Xiaohong Zi

Brain Research（2017）

Cited 16|Views6
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Abstract
•Mutant PS-2 activates p53 and miR-34a expression in PC12 cells.•Mutant PS-2 promotes PC12 cell apoptosis through triggering the p53/miR-34a axis.•Mutant PS-2 reduced the expression of miR-34a target gene Sirt1 and Bcl-2.
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Key words
The p53/miR-34a axis,Alzheimer’s disease,Presenilin 2,Apoptosis,Sirt1,Bcl-2
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