Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization

Julia Schanda,Chun-Wei Lee,Katharina Wohlan,Uta Müller-Kuller,Hana Kunkel,Isabell Quagliano-Lo Coco,Stefan Stein,Alexander Metz,Joachim Koch,Jörn Lausen,Uwe Platzbecker,Hind Medyouf,Holger Gohlke,Michael Heuser,Matthias Eder,Manuel Grez,Michaela Scherr,Christian Wichmann

HAEMATOLOGICA（2017）

Cited 11|Views34

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Abstract

RUNX1/ETO, the product of the t(8;21) chromosomal translocation, is required for the onset and maintenance of one of the most common forms of acute myeloid leukemia (AML). RUNX1/ETO has a modular structure and, besides the DNA-binding domain (Runt), contains four evolutionary conserved functional

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Key words

oncogenic activity,small molecule inhibitor,runx1/eto

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