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Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines

Kōzō Nagashima,Stuart D. Shumway,S. Sathyanarayanan,A Chen,Brian Dolinski, Youzhi Xu,Heike Keilhack, Tien-Tuan Nguyen,Maciej Wiznerowicz, L Li,Bart Lutterbach,Cloud P. Paweletz,Timothy J. Allison, Yong-Bin Yan,Sanjeev Munshi,Anke Klippel,Matthias H. Kraus,Ekaterina V. Bobkova,Sujal V. Deshmukh, Zhengfu Xu, U. Muêller,Alexander A. Szewczak, Bei Pan, Richon,Raphael E. Pollock,Peter Blume‐Jensen,Alan B. Northrup,Jannik N. Andersen

Journal of Biological Chemistry（2010）

Cited 0|Views26
Key words
allosteric kinase inhibitor,cancer cell migration,pdk1,tumor,anchorage-independent
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