Effect of INHALED ILOMEDIN on Biventricular Function in Postcardiotomic Patients with Low Cardiac Output Syndrome

Introduction: Low cardiac output syndrome (LCOS) complicates cardiac surgery and is still associated with high mortality rates of up to 65%. In addition it will exaggerate pulmonary arterial pressure leading consecutively to right ventricular dysfunction. Currently, a combination of vasopressors and inotropic agents are predominantly used to treat patients with LCOS. However, the administration can exacerbate myocardial ischemia and is incapable of treatment increased pulmonary arterial pressure. In contrast, ilomedin has been shown to improve not right ventricular (RV) afterload. Therefore, in the present study, we determined the hemodynamic effects of inhaled ilomedin in patients with LCOS as an “add on” therapy for patients in LCOS.