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The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans.

Monika Niewiadomska,Anna Janik,Urszula Perlińska-Lenart,Sebastian Piłsyk,Grażyna Palamarczyk,Joanna S. Kruszewska

Biochimica et Biophysica Acta (BBA) - General Subjects（2017）

Cited 3|Views12
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Abstract
•ALG13 gene encoding N-acetylglucosaminyl transferase in C. albicans•Expression of ALG13 gene influences expression of all members of Alg7/13/14 complex.•Defective N-glycosylation alters pathogenic attributes of C. albicans.•Expression of genes encoding highly glycosylated adhesins Als1 and Hwp1 is changed.•Cell wall of alg13 mutant contains much less mannose.
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Key words
Candida albicans,N-glycosylation,Alg13 N-acetylglucosaminyl transferase,Morphogenesis
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