A case of <i>H. pylori</i>-negative gastric MALT lymphoma treated by endoscopic submucosal dissection

A 59-year-old woman visited the previous clinic because of abdominal fullness. Esophago-gastro-duodenoscopy (EGD) showed a depressed lesion measuring 6mm in diameter at the greater curvature of the angle. She was diagnosed as gastric mucosa-associated lymphoid tissue (MALT) lymphoma on biopsy and was referred to our hospital for intensive examination and treatment. Both Helicobacter pylori antibody in serum and urea breath test were negative. The lesion was considered a minute H. pylori-negative MALT lymphoma and was resected by endoscopic submucosal dissection (ESD) . Pathologically, the lesion was curatively resected with ESD. For H. pylori-negative gastric MALT lymphoma, the response rate to H. pylori eradication is generally low, so and radiation therapy or chemotherapy may be selected. This case report suggests that ESD may be an alternative treatment for a minute H. pylori-negative gastric MALT lymphoma.