Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology

•Frontotemporal dementia is the second most common form of young onset dementia.•There is much clinical, pathological and genetic heterogeneity within FTD.•Mouse models focusing predominantly on recapitulating neuropathological and molecular changes of disease have been developed, expressing a single specific protein or genetic mutation.•Together with the species-typical presentation of functional deficits, this makes generalized conclusions drawn from these models that are directly translatable to humans difficult.•Understanding the phenotypical presentations in mice and how they may relate to clinical symptomology in humans is essential for advancing translation in FTD.