microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma
The Journal of Steroid Biochemistry and Molecular Biology(2017)
摘要
•The active hormone 1,25(OH)2D regulates miRs in prostate stroma.•Inflammation-related pathways were enriched in the putative targets for the 1,25(OH)2D-regulated miRs.•The miR-processing enzyme DICER1 positively correlated with 1,25(OH)2D in the stroma.•A high epithelial:stromal ratio of DICER1 protein levels associated with future biochemical recurrence.
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关键词
Vitamin D,Prostate cancer,microRNA,Prostate stroma
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