Electrophoretic separation of some nucleosides for the diagnosis of mastopathy and fibroadenoma
Journal of Analytical Chemistry(2017)
摘要
Mixtures of 13 normal and modified nucleosides in a 70 mM phosphate buffer solution (pH 6.7) supplemented with 100 mM of sodium dodecyl sulfate were separated by micellar electrokinetic chromatography in 25 min. Electrophoretic profiles of urine are obtained; it is demonstrated that 1-methylinosine and 1-methylguanosine nucleosides can be used as markers of precancerous states (mastopathy) and benign tumors (fibroadenoma).
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关键词
tumor markers, diagnosis of cancer, nucleosides, urine, micellar electrokinetic chromatography
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