Simvastatin Ameliorates Graft-Vs-Host Disease By Regulating Angiopoietin-1 And Angiopoietin-2 In A Murine Model

P. Zheng,Q-L Wu,B-B Li,P. Chen,D-M Nie,J. Fang,L-H Xia,Mei Hong

BONE MARROW TRANSPLANTATION（2017）

Cited 6|Views7

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Abstract

•Decreased levels of Ang-1 and increased levels of Ang-2 were involved in mice developing aGVHD.•Simvastatin prolonged mice survival and alleviated aGVHD symptoms.•Simvastatin improved Ang-1 production and inhibited Ang-2 release in vivo and in vitro.•Simvastatin might be a potent drug in the prophylaxis of aGVHD.

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Key words

Graft-versus-host disease,Angiopoietin,Simvastatin,Endothelial damage

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