Sensitivity And Applicability Of Six-Color Flow Cytometry Is Comparable To Aso-Primer-Real-Time Pcr (Rq-Pcr) For Minimal Residual Disease (Mrd) Monitoring In Adult Acute Lymphoblastic Leukemia (All) - A Comparative Analysis In 70 Patients From The German Multicenter Study Group For Adult Acute Lymphoblastic Leukemia (Gmall).

Although the quantification of MRD by PCR or flow cytometry (FC) is of proven prognostic value in ALL, both methods were never compared in adults. Since 3- to 4-color FC showed equal or inferior sensitivity to PCR in childhood ALL, we herein prospectively compared six-color FC (6C-FC) at initial diagnosis and during early follow-up in adult ALL to RQ-PCR as reference method.