The causal effects of alcohol on lipoprotein subfraction and triglyceride levels using a Mendelian randomization analysis: The Nagahama study

Yasuharu Tabara,Hidenori Arai,Yuhko Hirao,Yoshimitsu Takahashi,Kazuya Setoh,Takahisa Kawaguchi,Shinji Kosugi,Yasuki Ito,Takeo Nakayama,Fumihiko Matsuda

Atherosclerosis（2017）

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摘要

•Mendelian randomization analysis revealed causal effect of alcohol.•Alcohol increases high-density lipoprotein (HDL) cholesterol levels irrespective of its lipoprotein size.•Alcohol decreases total low-density lipoprotein (LDL) cholesterol levels.•Alcohol might worsen LDL profiles by increasing a proportion of small-dense LDL.•Alcohol decreases triglyceride levels.

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关键词

High-density lipoprotein,Low-density lipoprotein,Lipoprotein subfractions,Alcohol consumption,Mendelian randomization analysis

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