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Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain.

Masao Kawasaki,Takeshi Fuchigami,Nobuya Kobashi,Takehiro Nakagaki,Kazunori Sano,Ryuichiro Atarashi,Sakura Yoshida,Mamoru Haratake,Noriyuki Nishida,Morio Nakayama

Bioorganic & Medicinal Chemistry（2017）

Cited 8|Views16
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Abstract
We synthesized and evaluated a series of acridine derivatives as new SPECT imaging probes for prion deposits in the brain.
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Key words
Prion disease,PrPSc,Quinacrine,Acridine,Single photon emission computed tomography (SPECT)
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