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Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice

Takeyuki Shimizu,Satoshi Tateishi,Yuki Tanoue,Takachika Azuma,Haruo Ohmori

DNA Repair（2017）

Cited 3|Views11
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Abstract
•The role of Rad18-dependent PCNA ubiquitination in SHM was analyzed in Rad18 KO mice.•The frequency and the profile of SHM were similar in wild-type and Rad18 KO mice.•Low levels of ubiquitinated PCNA were observed in Rad18 KO cells.
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Key words
Somatic hypermutation,Immunoglobulin,Rad18,PCNA,DNA polymerase
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