Gata1-Centered Genetic Network on Chromosome 21 Drives down Syndrome Acute Megakaryoblastic Leukemia
BLOOD(2015)
摘要
Children with trisomy 21 (Down syndrome, DS) are predisposed to develop acute megakaryoblastic leukemia (DS-AMKL) as well as the antecedent transient leukemia (DS-TL). Mutations in the transcription factor GATA1 -leading to the exclusive expression of the shorter GATA1 isoform (GATA1s)- are present in nearly all children with DS-AMKL and DS-TL. GATA1s is both essential and sufficient to cause DS-TL in synergy with trisomy 21.
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关键词
chromosome,down syndrome,genetic network
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