The Correlation Between Cxcr7 Expression And Egfr Mutation In Non-Small Cell Lung Cancer

Abstract Objective: To explore the correlation between CXCR7 expression and EGFR mutation in NSCLC. Materials and Methods: Forty-nine paired cases of NSCLC carcinoma and para-carcinoma tissues were analyzed for the expression of CXCR7 mRNA by RT-PCR and CXCR7 protein by IHC. EGFR mutations were detected in carcinoma tissues by ARMS. T-test, one-way ANOVA and correlation analysis were used to analyze the data with SPSS software version 18.0. Results: In NSCLC, CXCR7 protein expression in carcinoma tissues was higher than in para-carcinoma tissues (14450±2049 vs 5206±1066, p<0.0001), while CXCR7 mRNA was not. In NSCLC, CXCR7 mRNA and CXCR7 protein expression levels were both related to the TNM stage (p = 0.007, p = 0.008) and metastatic status (p<0.0001; p<0.0001), but not to gender, age, smoking index and pathology. EGFR and CXCR7 protein were positively correlated (r = 0.289,p = 0.044) Conclusion: Like EGFR, CXCR7 can be used as a marker to predict the prognosis and guide clinical therapy in NSCLC. Keywords: CXCR7 RDC1 EGFR NSCLC Note: This abstract was not presented at the meeting. Citation Format: Yiping Han. The correlation between CXCR7 expression and EGFR mutation in non-small cell lung cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4830. doi:10.1158/1538-7445.AM2015-4830