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Acute arsenic exposure induces inflammatory responses and CD4+ T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2

Xiaoxu Duan,Shuang Gao,Jinlong Li,Liuzhong Wu,Yang Zhang, Wei Li,Lu Zhao,Jinli Chen,Shan Yang,Guifan Sun,Bing Li

Molecular Immunology（2017）

Cited 59|Views44
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Abstract
•Arsenic induced inflammatory responses in immune organs.•Arsenic affected CD4+ T cells differentiation in immune organs.•Arsenic mediated oxidative injuries in immune organs.•Arsenic activated MAPK, NF-kB and Nrf2 pathway in immune organs.
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Key words
TNF-α,ROS,NF-kB,MAPK,ERK1/2,JNK,Nrf2,Gata3,IFN-γ,HO-1,MPO,MDA,H2O2,CAT,GSH-Px,GST,Treg cells
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