Selective Aryne Formation Via Grob Fragmentation From The [2+2] Cycloadducts Of 3-Triflyloxyarynes
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2017)
摘要
A chemoselective ring-opening protocol of the formal [2+2] cycloadducts of 3-triflyloxyarynes was developed to generate 2,3-aryne intermediate via Grob fragmentation. A variety of 1,3-di- and 1,2,3-trisubstituted arenes could be readily accessed through this [2+2] cycloaddition-2,3-aryne formation sequence. The regioselectivity in these transformations originates from the steric repulsion of the aliphatic chain.
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关键词
Cycloisomerization
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