Clinical Management Of Small Cell Carcinoma Of The Urinary Tract (Sccut): A Single-Center Experience

216 Background: SCCUT is a rare but aggressive condition. No standard treatment has been established. The management of small cell lung cancer has been adopted by analogy. We aim to review the clinical features, therapy and natural course of patients with SCCUT. Methods: From 2002 to 2010 12 patients (pts) were diagnosed with SCCUT and treated at the Clinica Universidad de Navarra, Pamplona (Spain). Results: The median age was 62 (50-78). Male to female ratio was 11:1. The primary disease was prostate in 6/12 (50%) of cases, urinary bladder in 5/12 (41.7%) and kidney in 1/12 (8.3%). Overall, 5 pts (41.7%) had limited disease (LD) and 7 (58.3%) had extensive disease (ED) at onset. Basal serum levels of Neuronal Specific Enolase (NSE) were determined in 6 pts. In all of them levels over the upper-limit were observed. Treatment information was available for 10 pts, 5 with LD and 5 with ED. LD pts received multimodal therapy. Surgery (S) was the initial treatment in 4 pts (80%), 3 of them additionally receive...