Feeding the blend of organic acids and medium chain fatty acids reduces the diarrhea in piglets orally challenged with enterotoxigenic Escherichia coli K88

•We assessed effects of the blend of organic acids and medium chain fatty acids in piglets challenged with Escherichia coli K88.•The blend of organic acids and medium chain fatty acids improved growth performance of piglets challenged with Escherichia coli K88.•The blend of organic acids and medium chain fatty acids reduced post-weanling diarrhea incidence.