Crystal Structures of 1,3-Thiaza-4-one Heterocycles

The five-, six-, and seven-membered 1,3-thiaza-4-one heterocycles are known for their bioactivity. Five-membered 1,3-thiazolidin-4-ones are known to have a very wide range of biological activity, so much that the ring system has been referred to as a "magic moiety" or "wonder nucleus" [1]. Six-membered 1,3-thiazin-4-ones have often been investigated for their biological activity and are of potential medicinal use [2]. The activity of seven-membered 1,3-thiazepan-4-ones is exemplified by the investigational compound omapatrilat [3]. Crystal structures of 1,3-thiaza-4-one heterocycles recently obtained in our laboratory will be presented.