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CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening

Anna Köferle,Karolina Worf,Christopher Breunig,Valentin Baumann,Javier Herrero,Maximilian Wiesbeck,Lukas H. Hutter,Magdalena Götz,Christiane Fuchs,Stephan Beck,Stefan H. Stricker

BMC Genomics（2016）

Cited 18|Views19
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Abstract
The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The desire to deploy CRISPR-based methods in a large variety of species and contexts has created an urgent need for the development of easy, time- and cost-effective methods enabling large-scale screening approaches.
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Key words
gRNA library,Genome-wide,Cas9,Genetic engineering,Epigenetic engineering,Elongated protospacer,Epigenome editing
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