Arachidonic acid has protective effects on oxygen-glucose deprived astrocytes mediated through enhancement of potassium channel TREK-1 activity

Li Lu,Guangru Zhang,Chunli Song,Xuexi Wang,Weina Qian,Zhuanling Wang,Yanan Liu,Sheng Gong,Shuning Zhou

Neuroscience Letters（2017）

引用 5|浏览8

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摘要

•AA suppressed glutamate uptake and decreased GLT-1 levels under normal conditions.•AA alleviated OGD-induced astrocyte death.•AA rescued the decreased glutamate uptake under OGD conditions.•AA increased expression levels of GLT-1 and TREK-1 under OGD conditions.

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关键词

Arachidonic acid,Astrocytes,Oxygen-glucose deprivation,TREK-1

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