Fkpm, A Promising Solution For The Acute Pulmonary Thromboembolism

Background: With an extremely high morbidity and mortality, pulmonary thromboembolism (PTE) has greatly impacted the life quality of patients survived a thromboembolic event. PTE is mainly originated from blood clots from the venous system or the right heart, which clog the pulmonary artery or its side branches. Patients with deep venous thrombosis, heart diseases and certain malignancies have higher risk of PTE. Therefore, efficient and effective therapy against PTE is of great clinical significance. As commonly used thrombolytic drugs, tissue plasminogen activators (tPAs) convert plasminogen to plasmin, which primarily promotes dissolution of blood clots. FKPM is a genetically recombined human tPA, with a unique residue substitution, characterized by high biological activity, long half-time, and high stability. Here our studies have provided strong evidence for the advantaged thrombolytic potential of FKPM, in comparison to the well-acknowledged clinical thrombolytic drug against PTE, Alteplase.