High-throughput sequencing in acute lymphoblastic leukemia: Follow-up of minimal residual disease and emergence of new clones

•Repertoire sequencing (RepSeq) gives a deep insight of leukemic lymphoid populations.•High-throughput sequencing identifies new emerging clones at the time of relapse.•Clones of low abundance at diagnosis may become relapsing clones.•The Vidjil software enables both automated and interactive analysis of RepSeq data.