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Combination of the fluorescent conjugated polymer and 1, 4, 7, 10- tetraazacyclododecane-1, 4, 7-triacetic acid gadolinium chelate as an agent for dual-modal imaging

Luomei Yan,Liqiao Shen,Hua Zhou,Cunqi Wu,Yongxia Zhao,Lidan Wang,Xuexun Fang,Guangji Zhang,Jingwei Xu,Wei Yang

Tetrahedron（2016）

Cited 6|Views6
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Abstract
The macromolecule, PPV-NMe3+-DO3A-Gd, in which paramagnetic DO3A-Gd units were introduced into a fluorescent polymer PPV-NMe3+, was synthesized. It inherited the fluorescent properties of PPV-NMe3+ and gained the magnetic relaxivity of DO3A-Gd. PPV-NMe3+-DO3A-Gd was potential to function as a fluorescent/MRI dual-modal contrast agent.
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Key words
MRI contrast agent,Dual-modal imaging,PPV-polymer derivatives,CuAAC reaction,Gadolinium-DO3A
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