Idiopathic Non-histaminergic Angioedema: Successful Treatment with Omalizumab in Five Patients
Journal of Clinical Immunology(2016)
摘要
Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease characterized by AE resistant to antihistamines and a chronic course. We report five new cases of InH-AAE (two women and three men) with a rapid and dramatic response to the anti-immunoglobulin-E antibody omalizumab. In our literature review, we found 13 other relevant cases with a good response to this treatment. Overall, in 6 out of 18 patients, the doses of omalizumab required to prevent recurrences of attacks were higher than the licensed dose for chronic urticaria. No significant adverse effects have been reported.
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关键词
Idiopathic angioedema,non-histaminergic angioedema,omalizumab
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