Application of reporter strains for screening of new antibiotics

P. V. Sergiev,I. A. Osterman,A. Ya. Golovina,E. S. Andreyanova,I. G. Laptev,P. I. Pletnev,S. A. Evfratov,E. I. Marusich,S. V. Leonov,Ya. A. Ivanenkov,A. A. Bogdanov,O. A. Dontsova

Biochemistry (moscow) Supplement Series B: Biomedical Chemistry（2016）

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Abstract

Screening for new antibiotics remains an important area of biology and medicine. Elucidation of the antibiotic mechanism of action is an indispensable part for this type of research. Preferentially, it should be carried out quickly and cost-effectively, on the stage of primary screening. In this review we describe application of reporter strains for rapid classification of antibiotics by their mechanisms of action, without prior purification of active compounds and determination of their chemical structure.

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Key words

antibiotic, protein synthesis, bacteria, reporter strain, screening

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