PTU-118 Comparison of Anal Sphincter Function Using Solid-State and Water-Perfused High Resolution Anorectal Manometry (HRAM) In Healthy Volunteers: Abstarct PTU-118 Table 1

Introduction To compare anal sphincter pressure parameters using water-perfused (WP) and a solid-state (SS) HRAM catheter in healthy volunteers using a standardised protocol to provide normal values. Methods 60 asymptomatic volunteers were studied (20 M/40 F). WP HRAM single-use ano-rectal catheters (ARC), 10 channels, external diameter 14 Fr (MUI Scientific, Canada) and SS HRAM multi-use ARC, 8 channels placed 0.8 cm apart, external diameter of 12 Fr, 16 Fr at sensors (UniSensor AG, Switzerland) both distributed by Ardmore Healthcare, UK. Studies were performed consecutively in a randomised order with the volunteers in the left-lateral position with knees u0026 hips flexed. After a 3 minute familiarisation period, the following test manoeuvres were performed according to a standardised protoco, 1 Rest- subject relaxed and lying still, anorectal pressures measured for 1 minute. Cough- asked to cough once maximally. Squeeze- asked to squeeze maximally for 5 seconds. Cough u0026 squeeze manoeuvres were repeated twice. Sensation of maximum rectal capacity was assessed by gradual inflation of the balloon at a rate of 2 ml/sec using an automated pump. Results Normal values (5 th-95th percentile) for parameters of ano-rectal function in males u0026 females using. Conclusion Significant differences between the two systems were observed for maximum squeeze increment and maximum cough increment in males u0026 females (p Reference 1 Carrington EV, et al . Traditional measures of normal anal sphincter function using HRAM) in 115 healthy volunteers. Neurogastro u0026 Motility 2014; 26 (5):625–635. Disclosure of Interest None Declared