Deep sequencing methods for protein engineering and design
Current Opinion in Structural Biology(2017)
摘要
•Deep sequencing permits examination of local protein fitness landscapes.•NGS aids in engineering affinity and specificity for protein molecular recognition.•Application to enzymes is limited by paucity of functional selections.•NGS enables fundamental studies of enzyme behavior and evolution.•Gene tiling and molecular barcoding extend NGS to full-length proteins.
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