New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.

Five new cadinane sesquiterpenoids, pholiotins A-E (1-5), and three known compounds, 11-hydroxy-1(10)-valencen-2-one (6), 8,11-dihydroxy-1(10)-eremophilen-2-one (7) and durgamone (8), were isolated from the crude extract of Pholiota sp. Their structures were established on the basis of extensive spectroscopic analysis. Their absolute configurations were determined by X-ray diffraction, the Snatzke's method and electronic circular dichroism (ECD) calculations. All isolates were tested for antifungal activity.