Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents
Chinese Chemical Letters(2017)
摘要
Two series of new double pyrazole Schiff base derivatives 4a–4t and 5a–5p as anti-TMV agents were designed and synthesized, in which compound 4j showed the most potent anti-TMV activity. Molecular docking revealed 5-chloro-3-methyl-1H-pyrazole as scaffold of compound 4j could insert into the nucleotide sequence (GAAGUU) of Ori-RNA target pocket stably.
更多查看译文
关键词
Pyrazole,Schiff base,Anti-TMV,Molecule docking
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要