Asymmetric synthesis of chiral P-stereogenic triaryl phosphine oxides via Pd-catalyzed kinetic arylation of diaryl phosphine oxides
Tetrahedron Letters(2016)
Abstract
•A novel method for the synthesis of chiral P-stereogenic triaryl phosphine oxides is developed.•It is a Pd-catalyzed asymmetric C–P coupling via kinetic resolution.•High conversion rate and moderate to high enantioselectivity are observed.•A wide range of aryl iodides are found to work well under the catalytic system.
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Key words
P-stereogenic center,Triaryl phosphine oxides,Asymmetric catalysis,Cross-coupling,Kinetic resolution
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