EP06.04: Extracardiac malformation in prenatally diagnosed congenital heart diseases

To investigate the risk of extracardiac malformation (ECM) in prenatally diagnosed congenital heart diseases (CHD). This is a 10-year retrospective study of 492 women with fetal CHD diagnosed by prenatal ultrasound in our institution from 2005 to 2014. The types of CHD were grouped into 19 categories, the frequencies of ECM in each categories were evaluated. The risk of ECM was labelled as high (>30%), intermediate (10-30%) and low (<10%) depending on its prevalence. ECM occurs in 19.1% of patients with CHD. The most common ECM was central nervous system (n = 17), followed by genitourinary (n = 13), skeletal (n = 13), gastrointestinal (n = 10) and pulmonary (n = 9) anomalies. The CHD most frequently associated with ECM was truncus arteriosus (66.7%). Within the previously defined risk categorisation, high risk group consists of truncus arteriosus (66.7%), ventricular septal defect (42.0%), Ebsein's anomaly, tricuspid regurgitation and atrioventricular septal defect. Intermediate group consists of aortic stenosis, double outlet right ventricle, pulmonary stenosis, coarctation of aorta and complex anomaly. Low risk group is composed of transposition of great arteris (2.8%), persistent left superior vena cava (7.7%) and tetralogy of Fallot (9%). The risk of ECM in the CHD patients varies on the types of disease. We hope this study can help clinicians better counsel the patients with CHD.